Varga-Biro-Pejtsik: The shape of excitment

2018 Nikon-KOKI image contest results

Auro Science News

Images In the image category the first three winners honored with camera or binoculars sponsored by Nikon CEE and Auroscience Kft.. There were 11 candidates and 41 images. 10. László Bíró: Hydra Invasions Description: Fixed mouse visual cortical brain section, 30um green: Perineuronal nets labeled with Lectin from Wisteria floribunda agglutinin visualized by Alexa 488–conjugated secondary antibody blue: parvalbumin labeled …

Congratulations to Dr. Laszlo Barna on being awarded the Gabor Denes Prize!

Dr. Laszlo Barna was awarded the Gabor Denes Prize

Auro Science News

We are happy to announce Gabor Denes Prize of Dr. Laszlo Barna engineering physicist, leader of the Microscopy Center at the Institute of Experimental Medicine, Hungarian Academy of Sciences. Gabor Denes Prize has been established 30 years ago with the aim of recognizing unique innovations in the field of technology and engineering. Dr. Laszlo Barna has earned this important award …

Latest N-STORM 5.0 introduced at the Institute of Experimental Medicine, Hungarian Academy of Sciences

Latest N-STORM 5.0 introduced at the Institute of Experimental Medicine, Hungarian Academy of Sciences

Auro Science News

Professor Tamás Freund and Mr Takaharu Sasaoka cut the ribbon to officially introduce the new N-STORM 5.0 system at the Institute of Experimental Medicine, Hungarian Academy of Sciences Special symposium features STORM super-resolution imaging in life sciences Nikon Instruments has introduced the new N-STORM 5.0 at the prestigious Nikon Center of Excellence at the Institute of Experimental Medicine, Hungarian Academy …

Nikon:Imaging without Limits – Neuroscience Edition

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Explore neural networks from every angle, from the entire brain down to individual synapses Nikon provides a variety of cutting-edge bio-imaging products that are driving outstanding developments in the field of neural research. With its highly renowned technologies and extensive experience in advanced imaging systems, Nikon supports morphological observations and functional analyses of neural networks utilizing various observation depths, scales, …

STORM image

New paper in Acta Neuropathologica by KOKI researchers, using correlated STORM super-resolution imaging: “Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms”

Auro Science News

“Using a well-established model of alphaherpesvirus infection that reaches the brain exclusively via retrograde transsynaptic spread from the periphery, and in vivo two-photon imaging combined with high resolution microscopy, we show that microglia are recruited to and isolate infected neurons within hours. Selective elimination of microglia results in a marked increase in the spread of infection and egress of viral …

Co-transmission of acetylcholine and GABA regulates hippocampal states” published in Nature Communications by KOKI researchers, localised vesicle pools using STORM super-resolution imaging. Congratulation!

Auro Science News

Challenging a decades-old model of non-synaptic transmission of acetylcholine, we show that all hippocampal cholinergic terminals establish GABAergic synapses. We demonstrate that these synapses co-transmit GABA and acetylcholine via different vesicles, whose release is triggered by distinct calcium channels. This co-transmission evokes composite postsynaptic potentials, which are mutually cross-regulated by presynaptic autoreceptors. The GABAergic component alone effectively suppresses hippocampal sharp wave-ripples and epileptiform activity. This differentially regulated co-transmission suggests a hitherto unrecognised level of control over cortical states.

New paper on “Differential Excitatory Control of Two Parallel Basket Cell Networks in Amygdala Microcircuits” published in Plos Biology by KOKI researchers

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Researchers in the IEM HAS have discovered that in a hub of the fear circuits there are two parallel inhibitory microcircuits providing an equally strong control on neuronal spiking. These two inhibitory networks, however, receive distinct excitatory inputs. For instance, the AMPA receptor content in excitatory synapses along the dendrites of interneurons that belong to the two inhibitory circuits is different revealed by STORM. This study, in which neuroanatomical and electrophysiological techniques were combined with optogenetics, uncovered organizing principles of wiring between principal cells and inhibitory interneurons in a fear circuit that may be a general feature in cortical networks.

Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling

New paper on “Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling” published in Nature Communications by KOKI Scientists

Auro Science News

Researcher from the IEM-HAS discovered that back-propagating action potentials are not simply digital feedback signals in dendrites but also carry analogue information about the overall state of neurons. Using dendritic recordings, calcium imaging and glutamate-uncaging methods they showed that the analogue information about the somatic membrane potential modulate the dendritic action potential waveforms and local calcium influx enabling analog state-dependent long-term synaptic plasticity.